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Search Results for " syk inhibitor "

20

Compounds

Cat No. Product Name Synonyms Targets
T4391 Syk Inhibitor II dihydrochloride Syk Inhibitor II (hydrochloride) Others , Tyrosine Kinases , Syk , PKC , BTK
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet fun...
T9543 Syk Inhibitor II hydrochloride Others
The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of...
T4348 Syk Inhibitor II 5-HT Receptor , Syk
Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
T4263 BAY 61-3606 Syk inhibitor IV Apoptosis , Syk
BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
T70930 GSK SYK inhibitor
The immunoregulator spleen tyrosine kinase (SYK) is upregulated in cutaneous lupus erythematosus (CLE). This double-blind, multicentre, Phase Ib study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamic...
T62691 Syk Inhibitor II dihydrochloride dihydrate
Syk Inhibitor II dihydrochloride dihydrate is a highly selective, potent, ATP-competitive Syk inhibitor (IC50: 41 nM). Syk Inhibitor II dihydrochloride dihydrate exhibits anti-allergic effects.
T16776 RO9021 Syk
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
T39437 Cevidoplenib dimesylate Syk
Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.
TN1644 Flavanomarein Others
Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea...
T24843 Syk-IN-1 SykIN11,Syk-IN-11,Syk IN 11,Syk inhibitor-11,Syk inhibitor 11,Syk-inhibitor-11
Syk-IN-11 is a selective Syk inhibitor.
T6101 Entospletinib GS-9973 Syk
Entospletinib (GS-9973) (IC50= 7.7 nM)is a specific Syk inhibitor, which is orally bioavailable.
T11824LL Lanraplenib GS-9876 Syk
Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI ...
T14331 Gusacitinib ASN-002 JAK , Syk
Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).
T6594 MNS Syk , Src , p97
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
T0610 Piceatannol trans-Piceatannol,Astringenin Apoptosis , Serine/threonin kinase , PKA , Syk , PKC , Autophagy
Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is...
T28281 OXSI-2 OXSI 2,Syk Inhibitor Syk
OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.
T6115 Fostamatinib R788 FLT , Syk , Monoamine Transporter , Adenosine Receptor
Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
T3185 R112 (E)-Elafibranor Syk
R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase.
T2487 Cerdulatinib PRT2070,PRT062070 Tyrosine Kinases , JAK , Syk
Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.
T6174 R406 R-406 besylate Apoptosis , FLT , Syk
R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
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